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Emerging Science Extending Life Past 200 years

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Last Updated: 13 April 2019 by Marc Woodard

Believe it or not – biologically our bodies are capable of living 120 years. And that lifespan appears to be dependent upon many factors including our environment, culture and lifestyle.

One only needs to make a comparison from the early 1800s average life span and how short it was and how it increased from ~37 to 47 years of age by the end of the 19th century. By the mid-1950s one could expect to live an average life span of 68 years. Today, that average has now reached 79 years of age.

Like nature’s endless hand of time – so too we may experience..

Many scientists now believe a 120 year life span average is not impossible because of advancements in emerging genomic, and micro-Nano processing technologies. I know this all sounds Sci-Fi to many of you, but I assure you these emerging technologies are  real and advancing at warp speed.

Simply by viewing a window of time (~200 years) our average life span has increased 225%, or 44 additional years. To be fair, most of that 225% increase occurred during the mid-20th century due to the advancements of science. By today’s science – in order to achieve an average 100-120 year life span for a majority of any population… something within and outside of lifestyle, environment and conventional medical practices must change.

“With todays technology, its not so far fetched to believe the 120 year lifespan may soon be possible for a majority -rather than reserved for a few.”

Today the likelihood of living to the age of 100-120 years is reserved for a few. Yes, there are recorded individuals that lived 122 years. And in areas without official birth records, local clerics and residents have claimed they knew of people living past 150 years of age. With today’s technology, its not so far fetched to believe the 120 year lifespan may soon be possible for a majority rather than reserved for a few.

Let’s take a look at a couple of anti-aging and longevity experiments going on today. And in doing so better understand how one could live to 120 and beyond in good health. Also answer another question, can this longevity objective be achieved without advanced medical treatment through diet?

Recent studies show within rhesus monkey experiments at the University of Wisconsin, restricted diets slow down the bodies aging process. Although it is not understood exactly what mechanisms causes this – the studies show restricted calories simultaneously slow down the progression of disease as we age. So what do scientists take away from animal studies like these? By reducing daily intake 20-30% but not starvation dieting. It is said the CR (Calorie Restricted) diet could allow a human being to live maybe 135 to 140 years. Members of the Delaney’s group (Brian Delany is the president of Calorie Restriction Society) generally consumes fewer than 2000 calories a day. However it is also acknowledged by other restricted diet practitioners, it is not practical for a majority of population to endure a CR diet in hopes of achieving a 135-140 age result.

“The answers to fountain of youth solutions are being studied through a new millennial set of eyes.”

The answers to fountain of youth solutions are being studied through a new millennial set of eyes. These new age scientists believe it is now possible to extend human life by hundreds of years, not just decades or a century! So let’s look into their innovative mindset of how 100 or 200 years additional life could naturally progress to reality. The method to this madness is fueled by emerging sciences and technologies.

What are these technologies showing and telling us about weight management and ill-health prevention and control? By genetically turning-off the feeling of hunger without the subject feeling any sense of starvation. In the future, doctors will accomplish this task by having a patient swallow a nanobot pill that would switch on-off a DNA-gene string sequences that tell the brain 2000 calories of food per day is enough subsistence. Or how about a pill that was able to target a diseased gene string… then re-code and repair its DNA sequence. Wouldn’t this technology be of value to someone that is challenged with diabetes… heart condition or other ill-health conditions due to bad or addictive food habits?

In essence remove or short circuit a bad switch to cure disease, curve appetite and extend life…

Recall, it wasn’t long ago man believed it impossible to fly and send a man to the moon.

Science has acknowledged it possible to slow down the aging gene considerably through various genome treatments not yet discovered. In San Francisco there was a gene altering experiment on microscopic worms where their average life span is 13 days. Professor Cynthia Kenyon was able to increase some of their life spans by 6 times, simply by altering one specific gene and where the worms live a healthy productive life throughout the duration. This validates the genes that cause us to age are not fixed.

Lets take a closer look at the bio-genome discipline to understand how these advancing technologies make it possible to double life expectancy through genome technology. Geneticists [scientists who study genes and heredity] are making new discoveries everyday showing how it’s possible to biologically treat and cure disease and extend life. But in order to fully appreciate these possibilities a basic understanding of genetics and some presumptions must be made to grasp where this technology is heading and likelihood of patient treatment application within our lifetime.

… “no two people could ever have the same DNA gene code string sequences within a chromosome nucleus.”

There are approximately 30,000 genes that influence our growth and development throughout the human lifecycle. Now imagine how many combinations of DNA genetic code sequences could be made out of all of those genes that influence the metabolism, hormonal, circulatory, blood, skeletal and organ functions. And within these 30,000 gene combinations – they are completely different and unique than any other individual. That means no two people could ever have the same DNA gene code string sequences within a chromosome nucleus.

We all have 23 pairs of chromosomes that make up human attributes and sequenced in the same order of decreasing size. So at the 100,000 foot ceiling we can identify chromosome and some cellular genetic structures connected to a limited number of abnormalities.

What the cutting edge science is doing now that’s exciting within the realm of life extension possibilities. It’s what we now see occurring at ground level that’s revolutionary.

In order to relate to the new technologies being applied to chromosomes and DNA gene code sequence studies… it is best to paint this picture through an analogy you can identify with.

“When a chromosome book in the library is out of order it is easy to identify that missing out of place book.”

Our chromosomes are aligned in order like a library of encyclopedia books. That is, we can determine when a book is missing in our chromosome library. When a chromosome book in the library is out of order it is easy to identify that missing out of place book. However DNA genetic code strings bound onto a chromosomes nucleus is much harder to decode – similar to reversing a cellular mutation [i.e., illness, disorder and disease].

This is where understanding of genetics gets way more complicated but possible to define, relate and apply the path science must take to to break the average life extension barrier.

To reach this understanding we must first define genome. It is the complete set of genes or genetic material present in a cell or organism. These genes reside within the structure of any animal’s chromosome cells nucleus, where there are threadlike linear strands of DNA circled and bound to associated cell proteins. Humans have the same 46 types of chromosomes in number and order with the exception when it comes to sex determination. That is the 23rd pair of chromosomes is different. XX chromosome (female) and the distinctive XY chromosome (male).

Our unique genetic code resides within each chromosome [book]. And the DNA gene strings within each cells chromosomes are uniquely color coded with the genetic transcription of both parents. Therefore our genetic code sequence reads more like a story or words used within a books chapters and as unique as a finger print, or snow flake. Recall – No two people could ever have the same DNA coded story.

Now imagine a super-tiny micro bio-factory that could be introduced into the blood or immune circulatory system, that targets, re-codes and resets the aging or diseased chromosome gene code sequence. Just like updating a sentence within a books chapter. Although no two people have the same chapter stories – we all have the same book titles. It’s the individual ill-health story that reads wrong… whereby it now appears possible to edit and read right and rid the ill-health story within the body. Thereby reversing illness, disease and slowing down the aging process.

Genomics has advanced greatly over the last decade, now known as Genome Technology. The Genome Technology Branch (GTB) is a specialized group of research scientists that have developed world-class scientific control standards in innovative technology studies on gene isolation. This science allows gene isolation research to occur on a segment of a chromosome DNA molecule that codes and sequences, to include computational analysis of chromosome protein and linear DNA sequencing, etc. It is known through these studies that the color coding of our genes occupy certain space on a DNA gene string and on any one of 23 pairs of chromosomes in nearly every cell of our body. A blood sample is now the most common method to determine a biological DNA match. The same confirmation of genetic match can be found within the saliva, other bio-fluids, skin, hair and exoskeleton.

.. “within the 21st century science will be able to target a genetic defect(s) within a singular chromosome DNA string to cure cancer without second guessing treatment alternatives.”

If the chromosomes are the books that make up our library, then once opened the words and sentences are the 30,000 gene combinations of off-on switches that influence our unique growth and development, aging process and risk of acquiring disease. Now you can better understand how gene sequencing at the molecular level has unique DNA code per individual and why illness and disease (i.e., cancer, etc.,) is challenging to treat with current modern medicine and medical technologies.

It now appears likely one day soon and within the 21st century… science will be able to target a genetic defect(s) within a singular chromosome DNA string to cure cancer without second guessing treatment alternatives. And this will be accomplished by re-sequencing (and/or) turn on/off DNA gene strand connections as common treatment protocol. Whereby the cure will likely be treated through a bio-nanobot-factory processor that targets DNA defects within the books sentence structure [chromosomes nucleus].

What is a nanobot and how does it relate to these super tiny processor bio-factories better known as Nano robotics.

Nanobot is a new conceptual nanoscale organic-like robot (0.1 – 10 micrometers with ~1.5 nanometer switches). Its factory platform functions like a biochemical-medical repair center who’s processing size and speeds far exceed current computer processing technology. For example, our computer processors function in micro seconds (1 millionth of a second) on relative processor scale and platform. Where we’re heading in genome science is a super charged Nano-robotic processing time (1 billionth of a second) on a biochemical-compatible sized organic switching relay-repair platform that targets the sentence in need of editing.

Technololy has come a long way since… “The Constitution was adopted on September 17, 1787, by the Constitutional Convention in Philadelphia, Pennsylvania, and ratified by conventions in eleven states. It went into effect on March 4, 1789” [Bing Search Engine 2019]. You can’t help but think… what would they have thought about someone telling them a 100-200 years life extension was possible – well beyond their average 37-47 years life expectancy.

In the future these tiny bio-repair factories will be ideal to inject or consume as medicine that targets and makes the necessary cellular repairs. But we’re still too big to operate on a Nano-processing platform and don’t have a working prototype yet. However, the micro-processing scalability already exists and it just a matter of time before Nano processing technology becomes available for medical genome treatment on humans. As micro and Nano-processing technologies merge and advance, so does the microbiology and genomic mapping coordination to identify chromosome nucleus defects and re-coding a target site.

Using computer processer technology to advance genome science is possible because our body’s cellular structures function a lot like a computer processor. And the cellular functions of the body is mapped like a software code that makes DNA functional repairs possible through biochemical-electrical properties. Therefore it is more likely than not this technology at some point will be able to extend life, cure cancer and medical treatment as we know it today becomes dated and obsolete.

It’s only a matter of time…

It is possible within our lifetime to visit a medical doctor and be injected or swallow a pill that contains super-tiny organic bio-processor robotic factories that circulate throughout the blood stream and make necessary repairs, cure disease and slow down the aging process.

Regardless of how you feel about the science and the morality of it… anti-aging and advanced genome and other medical science and processor technologies are emerging industries… I’d literally take stock in.

References,

About.com. what is Binary? http://php.about.com/od/programingglossary/qt/binary.htm

Bionet. How Long Can we Live? www.bionetonline.org. http://www.bionetonline.org/english/content/ll_cont1.htm

National Human Genome Research Institute. Genome Technology Branch.  http://www.genome.gov/10000016 Peris, Richard. Dr. Could We Live Forever?

Or Even Come Close. 11 February 09. http://www.cbsnews.com/8301-3445_162-3475140.html

Sciences Education Foundation, General Atomics. Gene/Chromosome Gen/DNA Relationship Analogies.  http://www.sci-ed-ga.org/modules/dna/anals/genedna.html

The Free Dictionary. X Chromosome.  http://medical-dictionary.thefreedictionary.com/X+chromosome

Wikipedia.  Genomics.  http://en.wikipedia.org/wiki/Genomics

Wikipedia.  Nanorobotics.  http://en.wikipedia.org/wiki/ Nanorobotics

Woodard, Marc.  A Pill That Could Extend Life beyond 100 Years. Mirror Athlete Fitness Secrets.  23 November 2012.  http://www.mirrorathlete.org/2012/11/23/a-pill-that-could-extend-life-beyond-100-years/

Woodard, Marc. 10 Super Centenarians how’d They Live over 116? Mirror Athlete Fitness Secrets. 22 September 2012.  http://www.mirrorathlete.org/2012/09/22/10-super-centenarians-howd-they-live-over-116/

CRNano.org. Center for Responsible Nanotechnology.

What is Nanotechnology?  http://crnano.org/whatis.htm

Author: Marc T. Woodard, MBA, BS Exercise Science, ARNG, CPT, RET. 2015-19 Copyright. All rights reserved, Mirror Athlete Inc., www.mirrorathlete.org, Sign up for your Free eNewsletter.

How did They Live Past 116

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Healthy relationships contribute to long life spans

Updated: 22 December 2018

How do average people live well past 100 years of age and significantly longer with a 95 year average lifespan? Does it have anything to do with genetics, environment, habit, diet, exercise or something more or absent thereof?

First let’s examine some of the longest living centurion biographies on record. And after reviewing these biographies, we’ll connect the dots to make a correlation to their longevity lifestyle secrets.

During the 19th – late 20th Century – interviews before death relevant to lifestyle and culture to include biography and genealogy was not captured through a scientific or epidemiological process. Therefore I’ll render an opinion based on assumptions extracted from the limited amount of biographical data of deceased subjects; and references at the end of the article.

Super Centenarian – Deceased Subjects of Observation,

Jeanne Calment (21 February 1875 – 4 August 1997) she lived 122 years, 164 days, place of residence Arles, France. Jeanne Louise Calment surpassed previous Guinness Book of Record holders as the longest living confirmed human. It was said Jeanne smoked more than 2 cigarettes per day and after an operation in 1994 she weighed 99 pounds where she became dependent on a wheelchair for mobility. She attributed her long life and youthful appearance to olive oil which she used religiously in her food and on her skin. Included within her diet she drank port wine and consumed ~2 lbs of chocolate weekly. In total she outlived 329 undisputed-verified super centenarians

Sarah Knauss-Clark (24 September 1880 – 30 December 1999) she lived 119 years, 97 days, place of residence, Hollywood and Allentown, Pennsylvania. Sarah had a career as an insurance office manager and upon her marriage to Abraham Lincoln Knauss (December 19, 1878 – March 1, 1965) she spent her time as a home maker and was a skilled seamstress. Mrs. Knauss was known as an extraordinary woman that pushed the envelope of longevity. It was said, the reason for her longevity stemmed from the fact she was a very tranquil person and nothing fazed her. Also it is known that she enjoyed life because she had her health and could do what she wanted. Her interests and foods included: viewing golf tournaments, needlepoint and nibbling on chocolate turtles, cashews and potato chips. Her only child Kathryn Knauss Sullivan (November 17, 1903 – January 21, 2005) lived to be 101 and was 96 at the time of her mother’s death.

Lucy Hannah (16 July 1875 – 21 March 1993) she lived 117 years, 248 days, place of residence Born in Linden, Alabama and died in Detroit. She moved in the great migration to escape the racial tensions that were prominent of the times in the Deep South. Her parents survived slavery for which it is noted they were whipped daily until their freedom and thereafter suffered from trauma as a result of the physical and mental scars. Lucy married John Hannah in 1901 and had 8 children together. Two of her children were still living at the time of her death. The two sisters lived to be 100 years of age. And Hannah’s mother lived to the age of 99.

Marie-Louise Meileur (29 August 1880 -16 April 1998) She lived 117 years, 230 days, place of residence Kamouraska, Quebec, Canada. It is known that Marie was married twice and between the two marriages had 4 children with first husband Etienne Leclerc from 1900 and where he died in 1911. And then the super centenarian had six other children through her second marriage with Hector Meileur whom she married in 1915 until his death in 1972. She had 85 grandchildren, 80 great-grandchildren and 57 great-great- grandchildren and 4 (3 x great grandchildren). Marie’s death was the result of a blood clot.

Maria Capovilla (14 September 1889 – 27 August 2006) She lived 116 years, 347 days and was recognized by Guinness World Records during her reign as the world’s oldest living person ever in South America and the southern hemisphere in Guayaquil. Ecuador. It is also interesting to note she is also the oldest human that had a life span living within three centuries. Born as Maria Esther Heredia Lecaro; she married a military officer, Antonio Capovill after his first wife died. They had five children together, three (Hilda, 81, Irma, 80 and Anibal 78) of which were at Maria’s side prior to death. Antonio passed in 1949. She had 12 grandchildren, 20 great-grandchildren and 2 great, great grandchildren. She enjoyed watching TV, reading and walked without the assistance of a cane, but helped by an aide prior to the day of her passing. She also never smoked or drank hard liquor.

Although home bound for the last two years of life, she shared her home with eldest daughter Hilda and son-in-law. In an interview her traditional view of men and women stated her dislike, about how women today are permitted to court men, rather than men courting women.

During 2006 near time of death Maria’s health took a turn for the worse. She could no longer read, she nearly stopped talking and no longer could walk without the assistance of two people. Just prior to her death she was able to sit comfortably in her chair and fan herself. She died just 18 days before her 117th birthday. Cause of death Pneumonia.

Tane Ikai (18 January 1879 – 12 July 1995) She lived 116 years, 175 days, place of birth Kansei, Japan. She is the only fully verified person within Asia to reach 116 years of age. She married at the age of 20 had 3 sons and one daughter. At the age of 38 she left her husband. At the age of 89 she entered a nursing home. At the age of 109 she had a stroke where she remained bed ridden in a hospital until her death. Cause of death kidney failure.

Besse Cooper (26 August 1896 – 4 December 2012) 116 years and 100 days. Besse Berry Brown-Cooper of Sullivan County, Tennessee was married to Luther Cooper and had 4 children and widowed after 39 years of marriage. Luther was 68 at the time of his death. Mrs. Cooper lived on her farm and moved into a nursing facility at the age of 105. Recently, Cooper reached her 116th birthday in August 2012, the second-oldest verified person from Tennessee and surpassing Elizabeth Bolden who died in December 2006, at the age of 116 years and 118 days. When asked what the secret to her super centurion lifespan, she stated, minding my own business working outdoors and avoiding most junk foods and ate lots of vegetables. Occupation: retired teacher. Cause of Death: Respiratory Failure.

Elizabeth Bolden (15 August 1890 – 11 December 2006) She lived 116 Years, 118 days and at the time of her death recognized by Guinness as the oldest living person. She was born in Somerville, Tennessee, the daughter of freed slaves. She had 7 children, only two of which were alive at the time of her death (Esther, 89 and Mamie 86). Elizabeth had 40 grandchildren, 75 great-grandchildren, 150 great-great grandchildren and 220 (3 x great grandchildren) and an amazing 75 (4 x great grandchildren). And in her final days of life she resided within a Memphis Tennessee nursing facility. Elizabeth also lived a life spanning within three centuries.

Maggie Barnes (6 March 1882 – 19 January 1998) She lived 115 years, 319 days, place of residence, Johnston County, North Carolina. She was born to a slave and married a tenant farmer. Eleven of her children preceded her in death, while 4 of her other children survived her after death. Mrs. Barnes died of a complication from a minor foot infection.

Christian Mortensen (16 August 1882 – 25 April 1998) He lived 115 years, 252 days, last place of residence San Rafael, California. Born in a village near the city of Skanderborg, Denmark, he then settled in Chicago and worked various trades: tailor, milkman, and restaurateur and factory worker. He was married 10 years, had no children and never remarried. Retiring near Galveston Bay, Texas; 28 years later it was claimed at the age of 96 he rode his bike to the Aldersly Retirement Community in San Rafael where he stayed until his death. He’s the oldest living male to date.

When asked for advice on his long life; he stated, stay away from alcohol; drink lots of water, keep a positive attitude, keep good friends and singing will help you live a long time. His diet preferences were mainly a vegetarian diet and he also drank a lot of boiled water. He smoked cigars believing if in moderation, it was not unhealthy.

In order to find out how these 10 individuals lived so long – we’ll compare environment, lifestyle, diet, behaviors and habits with the online data available. In this way we may understand what common denominators may have contributed to their long life spans.

Centenarian interview statements revealed prior to death [in bold – represents a healthy habit or behavior of moderation], were claimed by each individual to contribute to their long lives spans.

Centurion Replies,

Use olive oil religiously in foods

Red Wine

Chocolate

Cashews

Potato chips

Drink lots of water

Mainly vegetarian

Drink boiled water

Junk foods

Hard Liquor

Rub olive oil on skin

Smoke Cigarettes and/or Cigars

Alcohol

Very tranquil person

Mind my own business, stress reduction

Keep a positive attitude and sense of humor

Perceived overall Good health

Needlepoint

Ability to be mobile

Singing

Watch TV

Listen to Radio

Watch Sports

Walking-mobility

Communication

Socialization

Working Outdoors

Good Family and friend relationships

Social gatherings

One has purpose in life

Interactive life

High Cancer Statisic- Environment (Reference article #11, 12, 13, 14)

California, Florida, Texas and New York (High Cancer States)

Centurions lived most of their life – on average in low cancer per Capita States

Cause of death,

Mobility loss

Blood clot

Pneumonia

Kidney Failure

Infection

No cause listed, respiratory failure

Conclusion,

It looks like all 10 of these individuals lived within large families; most were married and/or had large circles of various interactive social-family relationships. It also appears mobility, stress reduction and positive mood was important contributors to overall well-being. As far as their habits and diets – it appeared they moderated the good with a little bad. For the most part, their diets appeared healthy and most consumed very little if any alcohol.

Recall, 9 out of 10 of these super centenarians where female. It is a fact that women live longer than men. This has a lot to do with metabolism, genetics, diet, body weight, habits and lifestyle. What specifically separates men from women? Men are greatly driven by hormones (read importance of testosterone on men’s health, Ref #8) which tend to cause more risky behavior and mood-stress characteristics. Also when testosterone levels drop, or become unbalanced in men during the aging process, this change tends to have a significant impact on men’s health and longevity. Male hormone replacement therapy monitored by a physician can help with low testosterone production, which may help support vitality and longevity while reducing health risk.

All but one of ten centenarians lived in a statistically low cancer state(s) [excluding those that lived outside of the United States]. And all but one of the 10 was male. Christian Mortensen lived in Texas 28 years and then moved to a California nursing home at the age of 96. He lived ~48 years in a statistically high cancer state and where it appears he spent the majority of his first ~68 years of life in Skanderborg, Denmark. He lived ~116 years of age beating all other fellow men in longevity.

These centenarians show us they lived relatively balanced lifestyles. They were physically and mentally active throughout their life span; they enjoyed personal and social gatherings and relationships mostly within large circles of friends and family. And for those residing in the United States lived mostly within low statistical cancer states (Ref #11).

They lived purposeful and mobile lifestyles, had positive attitudes, maintained low levels of stress, had good sense of humor, enjoyed selfless endeavors and shared their life experiences and stories with others. They also lived life to the fullest and without the crutch of habitual vices and little need of medications.

Reference,

  1. Fadem, Mitch, Dr. Health Benefits of Cigar Tobacco Cigars and Medicine. The Tobacco Leaf “ Good or Bad? About.com. http://cigars.about.com/od/legalhealthissues/a/cigarmedicine.htm
  2. Rettner, Rachael. Sweet Science: The Health Benefits of Chocolate.  LiveScience.com.  11 February 2010. http://www.livescience.com/6111-sweet-science-health-benefits-chocolate.html
  3. Wikipedia.  The Free Encyclopedia. Oldest People.  http://en.wikipedia.org/wiki/Oldest_people#Oldest_people_ever
  4. Woodamarc.  How these Well Known Celebrities Lived So Long. Hubpages.com. 20 August 2012. http://woodamarc.hubpages.com/_sigsinmula/hub/How-Did-These-Well-Known-Celebrities-Live-so-Long
  5. Woodamarc. Pain Depression Origins. Hubpages.com. 5 April 2010.  http://woodamarc.hubpages.com/_sigsinmula/hub/Pain-Depression-Origins
  6. Woodamarc. Alcohol Consumption Good for You? Hubpages.com.  14 November 2008. http://woodamarc.hubpages.com/_sigsinmula/hub/Alcohol-Consumption
  7. Woodard, Marc. Disease is Scientifically Linked to Genetic Engineering of Food Crops.  MirrorAthlete Fitness Secrets. 22 September 2018.  http://www.mirrorathlete.org/2018/09/22/disease-is-scientifically-linked-to-genetic-engineering-of-food-crops/
  8. Woodard, Marc. Low Testosterone, another Man Made Risky Fix? MirrorAthlete Fitness Secrets. 22 January 2012. http://www.mirrorathlete.org/2012/01/22/low-testosterone-another-man-made-risky-fix/
  9. Woodard, Marc. Learn to Embrace the Pain, Exercise and Get Fit. MirrorAthlete Fitness Secrets. 23 September 2011.  http://www.mirrorathlete.org/2011/09/23/learn-to-embrace-the-pain-exercise-and-get-fit/
  10. Woodard, Marc. Wisdom of Consuming Oleic Acid [Olive Oil]. MirrorAthlete Fitness Secrets. 23 January 2010. http://www.mirrorathlete.org/2010/01/23/mae-healthblog-wisdom-of-consuming-oleic-acid-2/
  11. Woodard, Marc. Pancreatic Cancer Statistics and Recommendations. MirrorAthlete Fitness Secrets. 24 November 2009. http://www.mirrorathlete.org/2009/11/24/mae-health-blog-pancreatic-cancer-statistics-and-recommendations/
  12. Woodard, Marc. Is Pancreatic Cancer on the Rise? MirrorAthlete Fitness Secrets. 24 October 2009. http://www.mirrorathlete.org/2009/10/24/mae-health-blog-is-pancreatic-cancer-on-the-rise-part-1

Author: Marc T. Woodard, MBA, BS Exercise Science, ARNG, CPT, RET. 2018 Copyright. All rights reserved, Mirror Athlete Inc., www.mirrorathlete.org, Sign up for your Free eNewsletter.

Pill Extends Life to 100 Years and Beyond

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Last Updated: 23 May 2018, Marc Woodard

A substance taken as a pill has been studied over the last decade now shows further promise of extending life well over the centurion mark.  Whereas the average life span could exceed 100 years of age.

“That would be something considering the average life span today is 79.” This doesn’t seem so impossible to believe simply based on the fact the oldest living person recorded to date was Jeanne Calment who lived 122 years and 164 days .

Forever ageless like Face Rock, Bandon Beach, OR. Do you see the face?

Science has experimented with resveratrol concentrates in mice studies over the last decade where positive results show extended longevity, weight loss and decreased disease occurrences. However to receive similar benefits in humans relative to the animal studies would require the consumption of 1000 glasses of red wine [resveratrol resides in wine] daily equivalent dose. And no, “I don’t recommend consuming a lot of wine based on the study.”  However a high concentrate of resveratrol, or other phenol (plant) pill found in the marketplace may provide longevity benefits animal studies currently purport.

The questions than become 1) Do high resveratrol concentrate in supplement form exist?  2) Would it be safe to consume in high concentrate.  3) Are those healthy-longevity results seen in animal studies relative to human metabolism and health?

“So what exactly is resveratrol?”

1-2 glasses of 6-8oz red wine per day is said to be heart health.

It”s the trace phenol substance found in the likes of grape skin, seeds and vine that is the healthy component after harvesting and processing of red grapes to wine. That’s why nutritionists and health experts agree red wine is heart healthy if not exceeding two 6-8oz glasses per day. Alcohol volume is the health risk here. Whereas the heart healthy phenol [resveratrol] found in red wines is present in low concentrate.

Science also tells us this particular phenol (plant) substance is known to defend against harmful bacteria and fungi pathogens.

The most abundant source of resveratrol comes from vitis vinifera, labrusca, and muscadine grape sources used to make red wines. The highest concentrate source is from the skin of these grapes. There is ~50-100 micrograms (millionth/gram)/red grape source and by volume ~.30 – 1.07 milligrams (thousandths/gm)/resveratrol in a 5oz glass of wine.

Resveratrol is a secondary [stilbenoid] product which occurs naturally in a variety of plants (red grape, hops,  peanuts, Japanese Knotweed, melinjo fruit, mulberries, eucalyptus, spruce and lily). The phenol substance from the grape stilbenoid falls under the classification of flavonoids.

3-4 fruits and vegetable servings per day are recommended to sustain optimal health.

Flavonoids are found in fruits and vegetables which provide anti-oxidant benefits. High concentrate flavonoids also reside in seeds, nuts, green tea, buckwheat and pine bark. The best sources of anti-oxidant flavonoids are found in onions, tea and apples and of course red wines.

It appears through scientific animal studies a high concentrate of phenol substance daily also has the potential to reduce risk against cardiovascular, diabetes, cancer and Alzheimer’s disease, etc.

A 2006 study show mice served an over saturated fatty diet while taking 22mg resveratrol/kg of body weight/daily had a 30% lower risk of death as opposed to mice consuming the same high fat or restricted diet without concentrate. “Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival [Wade/Baur, et al. 2006]. Disagreement of transferable health benefits to human metabolism continued to be met with skepticism by the scientific community on topic.

However the scientific and anti-aging community may finally be more in lock-step based on the latest genomic medicine research related to this resveratrol-based 2006 longevity study.

Closest thing I had to a mouse on file for visual impact.. but I think much cuter than a mouse.

As of early 2013, there were no published clinical trials for resveratrol animal efficiency studies based in genomic medicine with regard to human age related disease.

However on 7 March 2013,

– Efficiencies relative to reservatrol and longevity connection was recognized possible through a target group of encoded gene known as a sirtuin. Or [SIRT1] appears to encode a member of the family of proteins that establish the human efficiency-benefit connection. To this date, “the science of aging has increasingly focused on sirtuins, a group of genes that are believed to protect many organisms, including mammals, against diseases of aging.”

Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin, SIRT1, that protects the body from diseases by revving up the mitochondria, a kind of cellular battery that slowly runs down as we age. By recharging the batteries, SIRT1 can have profound effects on health [Cameron 2013].

This is good news for the Anti-aging, medical and scientific community if these connections can be scientifically proven for human efficiency benefit. But what is a safe resveratrol concentrate dose today until SIRT1 trials can provide further data relative to anti-aging and longevity?

Body weight, activities, environmental stress and overall lifestyle differ with each one of us. Nutritional requirements vary with each person.

In 2006, an average daily concentrate was determined based on animal studies relative to a 175lb person. It would actually take 400mg resveratrol/kg of body weight/daily or 30,000mg/day to achieve the same efficiency claims made in the mouse studies using 22mg resveratrol/kg of mouse weight/daily.

This difference in dose adjustment for the human metabolism is necessary because ours is much slower than a mouse. Therefore the studies using 22mg resveratrol/kg of mouse weight/daily was not relevant to human efficiency benefits.

Here’s the adjustment dose difference from those trials. Instead of 22mg resveratrol/kg of mouse weight/day, the subject (mouse) would have to be fed a diet concentrate equivalent of 30,000mg’s resveratrol/kg body weight/daily for the study to be relevant for a 175lb person!  And If a person weighing 175lbs consumed ~400mg resveratrol/kg of human weight/daily it would likely present a toxicity problem [Wade/Baur, et al. 2006].

There have been no studies on mice using anywhere near a 30,000mg’s resveratrol/daily concentrate equivalent. But past studies on mice using concentrates as high as 300 mg resveratrol/kg of mouse weight/daily for up to 4 weeks had no adverse effect. However that’s not even close to the adjusted daily dosage for human efficiency studies. To understand the efficiencies on humans a metabolic dosage and/or sirtuins [group of genes] must be an adjusted dose on mice relative to human weight and metabolism.

Pacific NW Nutria – Lab rat it is not.

It would be interesting to see further animal studies that closely resemble the 30,000mg resveratrol human dose equivalent and what efficiencies/inefficiencies will be revealed in coordination with genetically coded research on humans.

Currently moderate resveratrol dosed supplements can be purchased in the marketplace. “Those who choose to consume 20 mg of resveratrol a day can take comfort in the BioMarker research showing that this potency exerted impressive changes in critically important genes involved in various aging processes and degenerative diseases.” However this statement is likely backed by the anti-aging research and marketers and not accepted by the scientific community until efficiency tests are proven in a controlled lab environment.

“Those who choose to consume higher doses of resveratrol can look at the media-reported studies that also showed very impressive results. The good news for consumers is that they can obtain standardized resveratrol and other grape constituents in 20 mg and 100 mg capsules, at a very moderate cost” [Life Extension 2007].

My advisement to the consumer, “Beware! Science truly has not proven the potential side effects and health risks when consuming a high dosage resveratrol (phenol) type, or like supplemental-herb diet product(s).”

To this date the efficiencies seen in animal studies do not equate to similar human benefits. If interested in taking resveratrol concentrate  – 20-100mg resveratrol concentrate appear safe.  However it is not clear whether or not a significant health or longevity benefit would result.

Investing in a HIGH phenol concentrate without scientific proof of efficiencies could be akin to throwing money down the drain. The off-set… lower dosages may be of health benefit.

Recommendation: There are two ways to make a consumer decision on topic:

Save your money on high concentrate phenol-herb supplements until science figures out an efficiency concentrate backed by the scientific community.

Taking a 20-100mg daily dose does not appear to present a health risk. It seems more likely than not resveratrol supplements at these dosages would improve metabolic efficiencies as opposed to increase health risk.

The decision to supplement diet with resveratrol at this point in time appears more likely a health benefit than not.

References,

Barrett, Stephen, M.D. Resveratrol: Don’t Buy the Hype. Quackwatch.org http://www.quackwatch.org/01QuackeryRelatedTopics/DSH/resveratrol.html

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (November 2006). “Resveratrol improves health and survival of mice on a high-calorie diet”. Nature 444 (7117): 337-42.

Cameron, David. New Study Validates Longevity Pathway. Harvard Medical School. President and Fellows of Harvard College. 7 March 2013. https://hms.harvard.edu/news/new-study-validates-longevity-pathway-3-7-13

Life Extension. What Dose of Resveratrol Should Humans Take? Life Extension. March 2007.  http://www.lifeextension.com/Magazine/2007/3/report_resveratrol/Page-04

Linus Pauling Institute. Micronutrient Information Center. Resveratrol. http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/

Peris, Richard. Dr. Could We Live Forever? Or Even Come Close. CBS news, 11 February 09.  http://www.cbsnews.com/8301-3445_162-3475140.html

Roizman, Tracey. Plant Sources of Resveratrol. LiveStrong.com. 7 February 2011.  http://www.livestrong.com/article/376085-plant-sources-of-resveratrol/

Wade, Nicholas (November 16, 2006). “Red Wine Ingredient Increases Endurance, Study Shows”. New York Times. http://www.nytimes.com/2006/11/17/health/17iht-web.1117wine.3582746.html

Woodard, Marc. 10 Super Centenarians how’d They Live Over 116? Mirror Athlete Fitness Secrets! 22 September 2012. http://www.mirrorathlete.org/2012/09/22/10-super-centenarians-howd-they-live-over-116/

Woodard, Marc. Was the Viking Culture Healthy? Mirror Athlete Fitness Secrets! 23 September 2010. http://www.mirrorathlete.org/2012/09/22/10-super-centenarians-howd-they-live-over-116/

Woodard, Marc. Epidemiology Provides Ill-Health Prevention and Centurion Wisdom. Mirror Athlete Fitness Secrets! 23 June 2010.  http://www.mirrorathlete.org/2010/06/23/epidemiology-provides-ill-health-prevention-centurion-wisdom/

Woodard, Marc. Alcohol Consumption Good, or Bad for your Body? Mirror Athlete Fitness Secrets! 25 September 2008. http://www.mirrorathlete.org/2008/09/25/mirror-athlete-enterprises-healthblog-alcohol-consumption/

Woodard, Marc. Why We Need Super Foods. Mirror Athlete Fitness Secrets! 23 December 2008. http://www.mirrorathlete.org/2008/12/23/mae-healthblog-why-we-need-super-foods/

Wikipedia. Resveratrol. http://en.wikipedia.org/wiki/Resveratrol

Author: Marc T. Woodard, MBA, BS Exercise Science, ARNG, CPT, RET. 2017 Copyright. All rights reserved, Mirror Athlete Inc., www.mirrorathlete.org, Sign up for your Free eNewsletter.